Kadsura coccinea, a member of the Schisandraceae family, is native to regions in China, Laos, Myanmar, Thailand, and Vietnam. Research on this plant has identified several active compounds with anti-rheumatoid arthritis (RA) and anti-inflammatory properties. These compounds were analyzed using the Swiss Target Prediction database to identify potential gene targets in Homo sapiens. Further, RA-related targets were obtained from GeneCards and MalaCards databases. A protein-protein interaction (PPI) network was constructed using STRING and visualized with Cytoscape to explore interactions among the predicted targets. This study highlights the potential of Kadsura coccinea in targeting inflammatory pathways, such as NF-κB and JAK 2 / STAT 3, for RA treatment.
Description
Kadsura coccinea is a plant species from the Schisandraceae family, found in South-Central and Southeast China, Hainan, Laos, Myanmar, Thailand, and Vietnam. Research on its bioactive compounds has revealed their potential in mitigating rheumatoid arthritis-related inflammation. Nine active compounds were selected for target prediction analysis based on in vitro screening results. Using the Swiss Target Prediction database, potential gene targets in Homo sapiens were identified. RA-related gene targets were further retrieved from GeneCards and MalaCards. Common targets were used to construct a PPI network via STRING and visualized using Cytoscape. The study suggests that these compounds may inhibit inflammatory pathways, including NF-κB and JAK 2 / STAT 3, offering insights into their therapeutic potential for rheumatoid arthritis.
Distribution
China South-Central · China Southeast · Hainan · Laos · Myanmar · Thailand · Vietnam
Synonyms
Kadsura coccinea var. sichuanensisKadsura chinensisKadsura calophyllaKadsura hainanensisKadsura ananosmaKadsura cavalerieiSchisandra hanceanaKadsura chinensis var. annamensisKadsura coccinea var. annamensisCosbaea coccineaKadsura coccinea var. coccinea
